This study examined the effect of rice production input variables and climate change variables on rice output in Nigeria. Data for this study such as temperature, rainfall, relative humidity, sunshine duration, land area, labour, capital and rice output from 1961 to 2020 were collected from various sources such as Nigeria Meteorological Agency (NIMET), World Bank online statistical depository, United Nations online database, United States Department of Agriculture Economic Research Service , Food and Agriculture Organisation Corporate Statistical Database , . Data were analysed using descriptive and inferential statistics. Specifically, the study revealed that rice output in Nigeria had a positive slope for the period under review. Land (coefficient = 0.212; p<1%), rainfall (coefficient = 1612.441; p<5%), relative humidity (coefficient = -81289.210; p<5%) and temperature (coefficient = 324766.300; p<5%) had statistically significant effect on rice output. Based on the findings of this study, it therefore recommends that there is need for rice farmers to adopt artificial irrigation in order to mitigate the effect of climate change for optimum rice productivity.