The research aimed to evaluate of water resources impact on development of agricultural economics in Egypt during the period 2000-2022. So this research based on descriptive and quantitative statistical analysis methods to estimate the proposed regression model. The most important results were, per capita share of available water and relative importance of agricultural production to GDP have taken a statistically decreasing trend, with an annual change rate of about -1.2% and -2% in average respectively. On other hand, agricultural labor, water and land unit productivity have taken a statistically increasing trend, with an annual change rate of about 13%, 12%, and 13% in average respectively during the study period. Also, it was found that a change of 10% in the quantity of water resources used in agriculture leads to a 3% change in cropped area at the same direction, a change of 10% in cropped area leads to a 96% change in agricultural production value at the same direction and a 10% change in agricultural production value leads to a 1.3% change in GDP at the same direction. Accordingly it is recommended to conduct more analytical studies to evaluate water resources impact on development of agricultural economic and, accordingly, on comprehensive economic development.