Today, food safety is the main priority for health of consumers. Recently, there is increasing in the consume of the poultry product in the World and European market. Groups of populations that consume poultry products industry searching them safety and guarantee. The contamination of fresh and packaged poultry meat and other poultry products derives from the environment and from the operating procedures applied by the companies of the production. The main objective of scientific research work is to reduce in the area of poultry sectors the degree of resistance of pathogens and their distribution. Methodology of this study is based on microbial analysis of air and their products in the poultry of Korça, isolation of pathogens microorganisms with method selection/incidence and identification of microorganisms with biochemical tests and preparations. The biochemical tests and experimental results showed that was isolated Pseudomonas spp. in outside sector and no Salmonella spp. was isolated. Measurement experimental show a large number of Escherichia coli in terrain DC. The number with E. coli in birds is bigger than in chickens to Korca poultry. E. coli is normal flora in part of cloaca as a microorganism of fecal contamination. The number of Salmonella spp. in these chickens and birds was zero. This is a very good indicator in the quality of poultry meat.