Abstract : This study aimed to evaluate the risk factors, common symptoms, and lesions of dogs infected with Canine Parvovirus (CPV) and the effectiveness of local herbal medicine in Thai Nguyen province, Vietnam. A total of 1414 dogs manifesting vomiting and diarrhea were tested using a rapid diagnostic kit test for CPV Ag (Canine Parvovirus Antigen Test). Dogs of all ages, breeds, genders, and seasons were infected with CPV, with an overall prevalence of 36.14%. The prevalence was higher in dogs younger than 3 months old (84.36%) compared to other ages (varying from 4.35 to 60.37%), the prevalence of imported dog breeds (43.07%) was higher than that of domestic breeds (33.69%) and the lowest was observed in hybrid breeds (29.58%), the prevalence in spring (49.75%) was higher than that in other seasons. In particular, unvaccinated dogs had a much higher rate of Parvovirosis (68.75%) than vaccinated dogs (6.6%). CPV is an infectious and highly contagious viral disease in dogs. Dogs of all ages, breeds, and genders were infected dogs infected with the disease exhibited damage in many internal organs, especially the gastrointestinal tract, heart, liver, and kidney. Using the extract of Pseuderanthemu palatiferum herbal medicine yielded similar results to using antibiotics in the treatment regimen for infected dogs.