Khok Nong Na model (KNNM) is currently introduced to farmers in Thailand as an efficient farm practice to operate agriculture, through maximizing land use and water conservation, to improve livelihood. This study focuses on farmers’ social-ecological factors influencing the adoption of KNNM. A questionnaire was systematically built based on bottom-up approach with elements of related literature. This was an attempt to formulate the fine-tuned questionnaire for the quantitative examination. Data collected from 200 farmers in Kut Chum district, Yasothon Province were used to study the social, economic, and environmental factors that determine the adoption of KNNM. The results showed that the most significant factor bolstering farmers’ adoption intention was environmental benefits such as adjusting the land use for being more suitable for agricultural activities. Also, the influence of social factors contributed positively to the adoption of KNNM was observed. Most notably, participating in KNNM to evolve farms to learning centers to earn respect from the community and the comprehensiveness of resources facilitated by organizations. These findings shed light on how to establish strategies to encourage farmers to embrace KNNM.