This study evaluated 10 sugarcane cultivars for their response to some biotic and abiotic factors limiting sugarcane cultivation in Nigeria. Cane setts of the cultivars were supplied by the National Cereal Research Institute (NCRI) Badeggi, Niger state, Nigeria. Planting was done on ploughed and harrowed soil, at the rate of 40 setts/plots and 1 m spacing. The total land area was 61 m x 19 m (1,159 m2). It was divided into 30 plots of 5 m x 5 m (25 m2). Cultivars were allocated to the plots randomly in a randomized complete block experimental design having three replicates. Data were collected for six months on sett germination, termite infestation, sett rot infection, disease incidence/severity and drought tolerance. All data were subjected to statistical analysis and mean separation using Minitab software. The results obtained showed a high percentage of sett germination for most cultivars, only N27 had below 50%. All cultivars were susceptible to termite infestation and sett rot infection, but the percentage termite infestation was low across cultivars, the highest being 10.83% (B991114 and B881104), while percentage sett rot infection was high in a few cultivars, as much as 55.00% in N27. Seven cultivars showed susceptibility to at least one of red rot, sugarcane white leaf and sugarcane mosaic diseases. Three cultivars were extremely susceptible to drought, while only two (BBZ951034 and B881104) exhibited tolerance. Two cultivars, B991114 and SP81-3250, had no incidence of any disease and were moderately tolerant to drought. There is a need for further work on them.